Topic: HSG4112 to treat obesity.
Background: HSG4112 is a synthetic analogue of glabridin an isolate from licorice. Glabridin is known to have anti-oxidative, anti-inflammatory and anti-atherogenic effects as well as a role in regulation of energy metabolism. The analogue HSG4112 has an energy expenditure- enhancing effect thus representing a promising candidate for treatment of obesity.
Task:
Give a concise and simple overview, in plain language, of the rationale behind the proposed project, the aims of this project, the proposal research design and the methods to be used to achieve those aims (400 words).
Provide an overview of the condition your drug is to treat. Why is it worth investigating? You should consider:
•The pathophysiology of the disease
•Existing treatments – pros and cons
•The impact on the individual & health system of the disease and treatment
•Overall burden of disease
– Introduction to Obesity disease (Burden of disease, current therapies available for obesity, current outcomes of those therapies, unmet needs of those therapies)
(1000 words)
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