Pharmacokinetics
Acetaminophen is rapidly absorbed from the GI tract, reaching peak levels in 0.5 to 2hours. It is extensively metabolized in the liver and excreted in the urine, with a half-life ofabout 2 hours. Caution should be used in patients with hepatic or renal impairment, which couldinterfere with metabolism and excretion of the drug, leading to toxic levels. Acetaminophen crosses the placenta and enters breast milk; it should be used cautiouslyduring pregnancy or lactation because of the potential adverse effects on the fetus orneonate
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