Purpose: To create a comprehensive handout with information on a medical conditi
Purpose: To create a comprehensive handout with information on a medical condition/disease of interest.
Instructions: Create a multi-page cliff-note on a specific disease or condition for which you have interest. While creating this document, imagine that it is meant to serve as a resource for clients and patients which can be provided by health counselors and care providers when they administer guidance and care following genetic testing. Content and formatting requirements are outlined in detail below. Read the rubric to learn how this assignment will be graded.
Formatting requirements:
File Specifications. Word Document (.doc or .docx) or PDF (.pdf) file created from a Word document.
Page Specifications. 8.5×11 inch paper, ½ inch margins, 2-column format. Line spacing of your choice, must not exceed page limit. There is no word minimum or maximum, however, be sure that you include the information requested below.
Length. The Cliff-Note must be 4-6 pages in length, including references.
Font. Arial, body text = size 11 and section headers = size 14.
Title. The first page must have a title header/banner at the top that is no more than 1.5 inches tall. The header can fill the entire width of the page. The font can be any size you prefer so long as the total height of the header/banner does not exceed 1.5 inches.
Tables and Figures. These count as visual aids in this assignment. Stock photos (avoid using copyright or licensed material) are also permitted as visuals but must be selected with care so that they connect important ideas or elicit certain thoughts/emotions when interacting with the Cliff-Note. Tables and figures must fit into 2-column format. Text in figures and tables must be a size that is readable if printed on a 8.5×11 inch piece of paper. Tables and figures must be numbered and have a title, for example, “Figure 3. Metabolic pathways influencing Crohn’s Disease.” Images, such as cartoons of fruits & veggies or a silhouette of person with obesity, are useful and encouraged – simple images such as these DO NOT require a title.
Visual and text content should be balanced. Over the entire length of this project (4-6 pages), the Cliff-Note should have approximately ½ of the space filled with text and the other ½ filled with visuals. This does not mean that each page needs to be half-and-half but overall, the totals should be relatively equal throughout.
References use & format. ALL borrowed ideas must be cited (when in doubt…cite it!). Paraphrasing requires citations; without citing you have committed plagiarism! All references should be cited in line with the relevant text, using numeric superscripts in the order in which the reference appears in the document. A reference list/bibliography must be included at the end of the document for all resources that were cited throughout. You must use AMA format for both in-text citations and reference list. The reference list can be included using a smaller font size (no smaller than size 9, Arial font) and must be in 2-column format.
Turnitin: Your assignment will be evaluated using Turnitin software (plagiarism evaluation). The report from Turnitin will be made available to you so please use this to your advantage. Wherever there are significant similarities in your writing (not reference list), make an effort to modify the wording so you do not lose points.
Reading Level: This assignment must be written at an 8th grade or lower level. You must determine the Flesch Kincaid Grade Level for your document – this must be 8.00 or LOWER! You can determine this in Word (File -> Options -> Proofing -> check the “Show Readability Statistics” box). When you want to check your document’s reading level, go to the “Review” tab and conduct a spelling and grammar check. When the check is completed, a box showing readability statistics will appear with the Flesch Kincaid Grade Level at the bottom of the list. You can also determine the Flesch Kincaid Grade Level at this website ( https://www.online-utility.org/english/readability_test_and_improve.jsp). Submission of a screen-shot of the “Flesch Kincaid Grade Level” reading level assessment for your Final Project is REQUIRED. The screen-shot must include text in the background showing that the assessment is from your Final Project.
Content requirements:
Title. The title must contain the following text: “Omics Insights: A Clinical Cliff-Note on _______.” You will fill in a disease or condition name in the blank.
References. A minimum of 10 references must be cited throughout this project (at least 1 per topic/item listed below, a-f). References may include scholarly websites, peer-reviewed journal articles (primary research, reviews, etc.), and text books. These must be cited in-text and in a reference list in AMA format.
Sections. You can title your individual sections as you wish. Feel free to be creative with this. The following topics must all be clearly addressed in the final document, and in an effort to help you stay on task with this project, assignments have been designed to guide you through collecting pertinent information relating to all areas of nutrigenomics which can inform patients and clinicians. You are welcome to use text content that you have submitted in assignments. You may need to modify the phrasing of your text so you can achieve the 8th grade reading level target (see above) and get the full points for this grading criterion.
Suggestion: Include a brief introduction (approximately 1-2 short paragraphs, 3-5 sentences each) to introduce the medical condition/disease of interest to your theoretical patient/client.
a. Single Nucleotide Polymorphisms (SNPs; Coincides with Assignment 2): Include a table of 3-5 SNPs which contribute to your chosen disease/condition. Some may be more directly related, while others are more peripherally related (i.e. affect secondary conditions or symptoms of the condition or disease you selected). This table should include the SNP IDs, the DNA nucleotide variant (e.g., G>C), the type of change in amino acid sequence that results for each (missense, nonsense, or none, if in an intron), and the gene that it is in/near. Also, discuss two of the SNPs in greater detail using paragraph or bullet-point format. To the best of your ability, discuss these SNPs in relation to dietary intake, how a client can address SNP-related dietary needs at home and if additional SNPs (in haplotypes) are related to the SNPs you chose to discuss.
b. Metabolomics (Coincides with Assignment 4): Identify 2-3 functional outcomes which relate to your chosen disease/condition. Functional outcomes are biological, biochemical, metabolic, and/or physiological alterations associated with the disease/condition. In lay terms, summarize the findings from one or more scientific articles related to your chosen disease/condition. The paper(s) you summarize must include metabolomics (review definition, if needed) results that might shed light on how metabolism of nutrients is altered in the disease/condition. Discuss specific metabolomics findings from the paper(s) in relation to the broader disease/condition or in relation to one or more SNPs/SNP-associated genes outlined above.
c. Microbiome (Coincides with Assignment 5): Identify 2 papers which discuss microbiome-related outcomes in response to diet or for your selected disease/condition/SNPs/SNP-associated genes. Summarize the scientific findings in lay terms so that a client would understand how their microbiome plays a role in nutrient metabolism and disease risk.
d. MicroRNA (Coincides with Assignment 6): Include a table of 2-4 microRNAs which contribute to/affect your chosen disease/condition. Some may be more directly related, while others are more peripherally related (i.e., affect secondary conditions or symptoms of the condition or disease you selected). In addition to the table, please describe what microRNAs are and what 1-2 of your selected microRNAs do in relation to your chosen disease/condition/SNPs/SNP-associated genes. To the best of your ability, discuss these microRNAs in relation to dietary intake and specific disease processes.
e. Meal Plan: Create a potential meal plan for ONE DAY that will address the above-mentioned areas (sections a-d) based on the current literature you have evaluated and findings shared in your Cliff-Note. Meal plan must be clearly organized into meals/snacks and all foods must be described in a way that someone could create the items with appropriate cooking methods. For example, if you don’t specify “grilled” a reader might think that they can deep-fry foods instead which might drastically change the nutritional content of the meal plan. Provide nutrition information which, at a minimum, includes the following meal plan content: per day kcal of protein, carbs, fat, fiber, and per day amounts (mg or mcg) of 4 micronutrients of your choice along with the recommended daily intakes in a separate column so that the meal plan can be compared to current recommendations for all adults. Include 1-2 paragraphs which explain how and why the diet was created to improve prevention or treatment of the selected disease/condition.
f. Metabolic Pathway Diagram or Flow-Chart: Please include at least one diagram or flow chart which illustrates a pathway from the above areas (sections a-d). The goal of this visual aid is to help readers understand the molecular or biochemical pathways that are occurring in their bodies and/or how their individualized nutrigenomics profile might cause them to respond to diets or metabolize nutrients differently under the chosen disease or condition. This figure cannot be more than a half page and must include a figure title which clearly explains what is being illustrated.
Click here for an AMA Style Guide:
Click here for an example layout for the Omics Insights Clinical Cliff-Note Project:
Grading: See specific grading criteria for this project in the Rubric.
Points: 145
Rubric
Final Project – Omics Insights: A Clinical Cliff-Note
Final Project – Omics Insights: A Clinical Cliff-Note
CriteriaRatingsPts
This criterion is linked to a Learning OutcomeTitleTitle wording as instructed
3 ptsFull Marks
0 ptsNo Marks
3 pts
This criterion is linked to a Learning OutcomeOverall Quality of Content & Display of Learning
10 to >5.0 ptsFull Marks
Clearly demonstrates new knowledge gained from course; statements are factual; course concepts are integrated throughout document
5 to >0.0 ptsSatisfactory
Any or all of the following: Modest indication that new knowledge gained from course; many unsupported statements or opinions; statements superficial, could have been made without much reading/watching of course content.
0 ptsNo Marks
10 pts
This criterion is linked to a Learning OutcomeContent Topic – Single Nucleotide PolymorphismHas all elements from instructions including table of 3-5 SNPs, paragraph or bullet-point detailed description of two of the SNPs, their relation to dietary intake, how a client can address SNP-related dietary needs at home. At least 1 topic-appropriate reference is cited (e.g., peer-reviewed journal article, course content, textbook, reputable professional organization website).
17 to >15.0 ptsOutstanding!
15 to >8.0 ptsMissing something…
Missing reference(s) (-2 pts) and/or some elements from instructions.
8 to >3.0 ptsProblematic
Missing reference(s) and/or major elements of instructions missing.
3 to >0 ptsUnsatisfactory
Missing most or all on this topic.
17 pts
This criterion is linked to a Learning OutcomeContent Topic – MetabolomicsHas all elements from instructions including 2-3 functional outcomes related the selected disease/condition and lay-terms summary of findings from one or more scientific articles the describes metabolism of nutrients. At least 1 project-appropriate reference is cited (e.g., peer-reviewed journal article, course content, textbook, reputable professional organization website).
17 to >15.0 ptsOutstanding!
15 to >8.0 ptsMissing something…
Missing reference(s) (-2 pts) and/or some elements from instructions.
8 to >3.0 ptsProblematic
Missing reference(s) and/or major elements of instructions missing.
3 to >0 ptsUnsatisfactory
Missing most or all on this topic.
17 pts
This criterion is linked to a Learning OutcomeContent Topic – MicrobiomeHas all elements from instructions including discussion of 2 papers about microbiome-related outcomes in response to diet or the selected disease/condition/SNPs and their associated genes. Lay-terms summary of scientific findings describes how the microbiome plays a role in nutrient metabolism and disease risk. At least 1 project-appropriate reference is cited (e.g., peer-reviewed journal article, course content, textbook, reputable professional organization website).
17 to >15.0 ptsOutstanding!
15 to >8.0 ptsMissing something…
Missing reference(s) (-2 pts) and/or some elements from instructions.
8 to >3.0 ptsProblematic
Missing reference(s) and/or major elements of instructions missing.
3 to >0 ptsUnsatisfactory
Missing most or all on this topic.
17 pts
This criterion is linked to a Learning OutcomeContent Topic – MicroRNAHas all elements from instructions including table of 2-4 microRNAs that contribute to/affect selected disease/condition. Description of what microRNAs are and what 1-2 selected microRNAs do in relation to selected disease/condition or SNPs./SNP-associated genes. Discussion of these microRNAs in relation to dietary intake and specific disease processes. At least 1 project-appropriate reference is cited (e.g., peer-reviewed journal article, course content, textbook, reputable professional organization website).
17 to >15.0 ptsOutstanding!
15 to >8.0 ptsMissing something…
Missing reference(s) (-2 pts) and/or some elements from instructions.
8 to >3.0 ptsProblematic
Missing reference(s) and/or major elements of instructions missing.
3 to >0 ptsUnsatisfactory
Missing most or all on this topic.
17 pts
This criterion is linked to a Learning OutcomeContent Topic – Meal PlanHas all elements from instructions including meal plan for 1 day that addresses other “Omics” sections in Cliff Note and literature cited therein. Meal plan is clearly organized into meals/snacks and all foods are described in a way that someone follow it appropriately (i.e., portion, cooking method). Nutrition information is provided, at a minimum includes: total kcal, kcal of protein, carbs, fat, fiber, and weight amount of 4 micronutrients along with the recommended intakes for adults for all items in a separate column. 1-2 paragraphs explaining how and why the diet was created to improve prevention or treatment of the selected disease/condition.At least 1 project-appropriate reference is cited, other than the source for nutrient calculation (e.g., peer-reviewed journal article, course content, textbook, reputable professional organization website).
17 to >15.0 ptsOutstanding!
15 to >8.0 ptsMissing something…
Missing reference(s) (-2 pts) and/or some elements from instructions.
8 to >3.0 ptsProblematic
Missing reference(s) and/or major elements of instructions missing.
3 to >0 ptsUnsatisfactory
Missing most or all on this topic.
17 pts
This criterion is linked to a Learning OutcomeContent Topic – Metabolic Pathway or Diagram Flow ChartHas all elements from instructions including at least one diagram or flow chart which illustrates a pathway from the “Omics” topics. Figure is not more than a half page and includes a title that clearly explains what is being illustrated. At least 1 project-appropriate reference is cited, other than the source for nutrient calculation (e.g., peer-reviewed journal article, course content, textbook, reputable professional organization website).
17 to >15.0 ptsOutstanding!
15 to >8.0 ptsMissing something…
Missing reference(s) (-2 pts) and/or some elements from instructions.
8 to >3.0 ptsProblematic
Missing reference(s) and/or major elements of instructions missing.
3 to >0 ptsUnsatisfactory
Missing most or all on this topic.
17 pts
This criterion is linked to a Learning OutcomeDocument FormattingFollows all assignment formatting instruction (Word doc, page specifications, length, font type and size, title size and placement, balance of text and visual elements is approximately 1/2 and 1/2); is creative in layout and style. [Reading level and referencing – scored separately.]
10 to >5.0 ptsFull Marks
5 to >0.0 ptsSatisfactory
0 ptsNo Marks
10 pts
This criterion is linked to a Learning Outcome8th Grade Reading LevelEight grade reading level achieved; screen shot provided documenting reading level (even if not at 8th grade level)
5 ptsExcellent!
3 ptsGood effort!
Didn’t make 8th grade level but got close!
0 ptsNo Marks
Far from 8th grade level and/or no documentation submitted of reading level.
5 pts
This criterion is linked to a Learning OutcomeReferencingAppropriate and responsible use of and sources of references; document includes evidence-based information cited in-text where appropriate; absence of unsupported claims/opinions; at least 10 references cited, AMA format used with in-text citations and reference list/bibliography at end.
7 ptsFull Marks
At least 10 references are in AMA format in-text and in references list; citations clearly support writer’s points; are properly integrated into document (not just dropped in or randomly cited); citation sources are evidence-based and/or are reputable.
3 ptsModerate
References partially support writer’s points; in-text and/or references list not in AMA format; integrated as generalizations rather than strategically; lack evidence-base or professional credibility; less than 10 references.
0 ptsPoor
Less than 5 references are used; evidence for statements is generally flimsy and not properly supported; not in AMA format.
7 pts
This criterion is linked to a Learning OutcomeQuality of ProseGrammar, proof-reading, flow of concepts/text.
8 to >4.0 ptsOutstanding!
Entire Cliff Note content (text, tables and figures) is clear and articulate; has correct grammar and punctuation; no typographical errors
4 to >0.0 ptsQuality lacking
Some lack of clarity in text, table, or figure content; contains several proofing errors; is understandable but contains minor grammatical errors
0 ptsPoor Quality
Contains multiple grammatical and proofing errors; is not professional; is difficult to understand or follow flow of ideas
8 pts
Total Points: 145
